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Cristiano Ronaldo is suspended, while the likes of Wayne Rooney and Dimitar Berbatov are likely to be rested for this clash. Nevertheless, the layers are taking few chances when it comes to Manchester United, despite their poor recent record in this competition. Boylesports stick their neck out (!) and offer 1/2 that they make short work of Blackburn, while Ladbrokes and Skybet go 2/5.

It's likely that only one or two players that featured in Sunday's Manchester derby will be in action on Wednesday evening, but are Rovers (11/2 Stan James) good enough to take advantage of a weakened home team? After all, this is a side without a league win in nine matches, although they did win at Sunderland (2-1) in the last round of the Carling Cup.

Roque Santa Cruz opened the scoring on that night, and the Paraguayan is 9/1 (Paddy Power) to repeat the trick here. Fellow South American Carlos Tevez was on target for United in the previous round against QPR and he's 4/1 (bet direct) to score the first or last goal.